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Compared with saline and free-drug controls, TBP-NP-treated mice demonstrated significantly improved range of motion and enhanced mechanical properties, confirming effective tendon-specific targeting and functional repair ( In vitro , PDGF-BB cmRNA enhanced tendon cell proliferation and migration, while IL1RA cmRNA reduced pro-inflammatory cytokine expression

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Given the potential relevance of these findings, it will be essential to validate the results in patient samples and correlate them with clinical information and dietary habits

Endoplasmic reticulum stress After HS, a large number of misfolded proteins accumulate in the body, triggering endoplasmic reticulum stress (ERS) in cells

However, tGSH in the ALS group was significantly higher than that of the HC group for the first (1.33-fold, P = 0.0215) and the second (1.50-fold, P = 0.0143) visits

372 For instance, patients undergoing radiotherapy or chemotherapy for malignancies are at risk of uric acid nephropathy and may require preventive therapy with intravenous hydration and xanthine oxidase inhibitors