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10.1016/j.cbpa.2021.111040 159 LiuD.PellicerA

2025 Oct 7

SMAD4 is essential for the TGF-1-induced epithelialmesenchymal transition (EMT), and can downregulate GPX4 expression, consequently increasing vulnerability to ferroptosis

Consistent with this classification, we report highly conserved P XXX( T / S )XX C (C P ) active site motifs for each of the three subfamilies across both metazoans and non-metazoans (Fig