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Current serotonin medications are aimed at increasing central 5-HT neurotransmission in the brain, and there are no approved indications for manipulating peripheral 5-HT, though peripheral 5-HT synthesis is being considered as a potential target for developing pharmacological agents in some disorders ( We are not aware of prior studies reporting low S-5-HT in hypothyroidism or CFS

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doi:10.1159/000524627 [7] Gerentes M, Pelissolo A, Rajagopal K, Tamouza R, Hamdani N

Evening dosing delivers reduced efficacy but not zero efficacy

The association of GSTM1 deletion polymorphism with lung cancer risk in Chinese population: Evidence from an updated meta-analysis