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The investigators interpreted the effects as direct pharmacological validation of the NNMT-knockdown phenotype reported earlier in genetic models

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2 Grip Strength and Exercise Endurance in Aged Mice Dimet-Wiley et al., Scientific Reports (2024) This study compared 5-Amino-1MQ treatment, voluntary wheel-running exercise (PoWeR), and combined treatment in aged C57BL/6J mice