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Elevated homocysteine levels have been associated with neurodegenerative diseases

doi: 10.1007/s00429-011-0308-y 115 ParkerA.RomanoS.AnsorgeR.AboelnourA.Le GallG.SavvaG

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The majority of patients had non-alcoholic steatohepatitis (NASH, 36%) or combination of alcohol-related liver disease and NASH (27%)

Conclusion: While a significant increase in Ybx1 expression in differentiating preadipocytes may support healthy adipogenesis, our findings reveal a detrimental mechanism in which the maladaptive activation of Ybx1 within hepatocytes directly stimulates the C/EBP:PPAR pathway, leading to an increase in adipogenic gene expression that becomes lipotoxic within the liver

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