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These include intranasal administration, which allows NGF to bypass the BBB and reach brain parenchyma, and the development of NGF-mimetic small molecules or selective TrkA agonists (Rogdakis et al., 2022

Treatment of TLS requires vigorous intravenous hydration (Mughal 2014

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Dosing & Reconstitution Guide Educational guide for reconstitution and daily dosing Standard / Gradual Approach (3 mL = ~1.667 mg/mL) Frequency: Inject once daily subcutaneously (typically in the morning on an empty stomach)