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GHK-Cu, a naturally occurring tripeptide, has been shown to enhance the expression of genes associated with wound healing and skin regeneration by activating pathways involved in collagen synthesis, such as transforming growth factor-beta (TGF-) and extracellular signal-regulated kinases (ERK)

Synergistic interactions between GSTs and efflux pumps have also been observed in several studies 68,70

However, the effect varies, is not guaranteed, and the evidence is still limited

Collagen and Fibroblast Activity It appears to enhance fibroblast migration and collagen organization, which are essential for tendon and ligament healing. 3

Weinstock LB, Klutke CG and Lin HC: Small intestinal bacterial overgrowth in patients with interstitial cystitis and gastrointestinal symptoms

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