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Rivard A, Fabre JE, Silver M, Chen D, Murohara T, Kearney M, Magner M, Asahara T, Isner JM (1999) Age-dependent impairment of angiogenesis

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Portugal, with a purity of 99.5%, or vehicle (tap water) was administered by gastric gavage (200 L) to D 2 / and D 2 +/+ mice

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In vitro , PYC exhibits antioxidant effects during adipogenesis by downregulating the mRNA expression of pro-oxidant enzymes, such as nicotinamide adenine dinucleotide phosphate hydrogen oxidase 4 and glucose-6-phosphate dehydrogenase, while simultaneously upregulating antioxidant enzymes, including Cu/Zn-SOD, Mn-SOD, GPx, and GSH reductase ( ex vivo studies show that PYC acts synergistically with lutein to reduce oxidative stress in porcine retinal homogenates ( In a study using Escherichia coli mutants, PYC induced the expression of key antioxidant enzymes such as MnSOD and CuZnSOD, particularly under oxidative stress, suggesting a potential antioxidative role (Youm and Kim, 2003)

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