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Structures for juglone, p-benzoquinone, 2,5-dihydroxy 1,4 benzoquinone, DDQ (2,3-Dichloro-5,6-dicyano-1,4-benzoquinone), 1,4-naphthoquinone, lawsone, and plumbagin were downloaded from PubChem

For instance, DSF has been shown to reduce NF-B p65 phosphorylation and nuclear translocation in various cell types, leading to decreased expression of NF-B target genes like TNF- and IL-6 (Kannappan et al., 2021)

Demyelination of brain cells is commonly seen in dementia patients

Meanwhile, the significant elevation in hepatic MDA levels was due to AZA-induced oxidative stress, triggering the generation of free radicals that harm liver and kidney cells by causing lipid peroxidation (29)

While many reviews have focused on Mn homeostasis, the aim of this review is to concisely synthesize what we know about its effect primarily on the nervous system with respect to its role in protein misfolding, mitochondrial dysfunction, and consequently, neuroinflammation and neurodegeneration

It became relevant when someone figured out how to get it into cells at therapeutic concentrations