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Administering antioxidants prior to or alongside gonadotoxic treatments may mitigate ROS induced damage to spermatogenic cells, thereby preserving endogenous sperm production

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Conversely, increasing NNMT expression in primary hepatocytes resulted in elevated glucose output and increased expression of Pck1 and G6pc

Reduced glutathione (GSH) is a major intracellular antioxidant neutralizing free radicals and detoxifying electrophiles