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Microvascular reactivity and inflammatory cytokines in painful and painless peripheral diabetic neuropathy

Release of glutamate peripherally results in inflammation, pain, and edema (11)

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Nascobal Dosage and Administration 2.1 Testing and Other Considerations Prior to Dosing Prior to treatment, obtain hematocrit, reticulocyte count, vitamin B12, folate, and iron levels [see Dosage and Administration (2.4)]