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Nanocarriers have been shown to have a transient effect on targeted transporter plasma membrane localization as, after binding, the nanocarrier-transporter complex is internalized in the cell followed by recycling of the transporter back on the plasma membrane (82)

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However, the NAC monotherapy arm (600 mg three times daily) showed a trend toward slower decline in forced vital capacity (FVC) that did not reach statistical significance compared to placebo (Martinez et al., N Engl J Med, 2014) [45]