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MEK inhibitor AZD6244 induces cell growth arrest and synergizes with Nutlin-3a-mediated cell death by upregulating p53 and PUMA levels in AML

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However, a significant proportion of patients are still refractory to pharmacological treatments, so the development of new drugs targeting the underlying mechanisms of UC is necessary to achieve optimal disease control

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The first studies investigating the role of physical exercise on ALS onset and progression demonstrated a beneficial effect achieved by an endurance training protocol in SOD1 G93A mice (Kirkinezos et al., 2003)