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pH-responsive poly(ethylene glycol)/poly(L-lactide) supramolecular micelles based on host-guest interaction

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However, their dysregulation can exacerbate inflammation and tissue damage in ARDS ( Given the central role of oxidative stress and lipid peroxidation in ARDS, targeting ferroptosis represents a promising therapeutic strategy ( 2 Ferroptosis in infection and ARDS development Cell death pathways play critical roles in immune homeostasis, infection defense, and inflammation resolution

10.1016/j.freeradbiomed.2013.07.008 110 Vieira JuniorR

Conversely, overexpression of myo-inositol oxygenase in proximal renal tubules can exacerbate ferroptotic damage in the kidneys of mice treated with cisplatin (161)

Figure 2 Later several studies in humans confirmed these animal findings