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Tesamorelin is an FDA-approved prescription drug (brand name Egrifta), cleared in 2010 on the strength of multiple Phase 3 double-blind, placebo-controlled randomized trials for a specific, narrow indication: reducing excess abdominal fat in people with HIV-associated lipodystrophy

doi: 10.1007/s10067-008-0964-3 101 WoodrickRSRudermanEM

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The histidine position is therefore not interchangeable, and its specific placement at residue 2 is what makes the GHK sequence a high-affinity copper-binding motif

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