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The extracellular concentrations of the acylcarnitines were compared with the experimental data and the least sum of squares was the objective function to be minimized: in which E is the objective value, P is the tested parameter set, x i,j is a point in the dataset, and y i,j ( P ) is the corresponding simulated value

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Acknowledgments We thank LetPub (www.letpub.com) for its linguistic assistance during the preparation of this manuscript

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