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Extracellular NMN must be converted to NR by the 5-nucleotidase CD73 before being taken up intracellularly and then converted back to NMN by nicotinamide riboside kinase 1 26

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J Neurosci Res 87:408417 Sultana R, Newman SF, Abdul HM, Cai J, Pierce WM, Klein JB, Merchant M, Butterfield DA (2006) Protective effect of D609 against amyloid-beta1-42-induced oxidative modification of neuronal proteins: redox proteomics study