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doi: 10.1126/scitranslmed.aah4477 Summary Keywords metabolic syndrome, atherosclerotic cardiovascular disease, hypertension, endothelial dysfunction, platelet hyperactivity Citation Das D, Shruthi NR, Banerjee A, Jothimani G, Duttaroy AK and Pathak S (2023) Endothelial dysfunction, platelet hyperactivity, hypertension, and the metabolic syndrome: molecular insights and combating strategies

Under non-stress conditions, Nrf2 remains tethered to Keap1, which promotes its ubiquitination and degradation, keeping Nrf2 activity low 65,66

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The somatotrophic system involves circulating GH and IGF1, and the local production (autocrine or paracrine) of GH and IGF1 in several tissues (Figure 1)

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