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Despite their benefits, antioxidants can have side effects

Neuron 105, 10771093 e7

Melatonin alleviates the heat stress-induced impairment of Sertoli cells by reprogramming glucose metabolism

In brief, the Caco-2 cells were cultured in Dulbeccos modified Eagles medium (DMEM) supplemented with 10% fetal bovine serum (FBS) at 37C with 5% CO 2

As a result, NRF2 is freed from Keap1, with which it forms a complex, and is translocated into the nucleus where it binds to antioxidant responsive elements (AREs) in the promoters of target genes (Fig