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First, many patients have already tried the evidence-based methods and have found them to be unhelpful.13-16 Indeed, even with the best combination of evidence-based treatments, only about 1 in 5 smokers will be abstinent 612 months later.12 Most lung cancer patients do try to stop smoking when given the bad news about their cancer diagnosis, but a significant percentage relapse back to smoking.7,8 Mostly, what clinicians tell patients who have relapsed is to try harder to quit, often recommending the same failed treatment options again

When these attempts fail, the organelle will be targeted for removal by autophagy, a process known as mitophagy

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