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Physiologically, and similar to apoptosis of nucleated cells, eryptosis occurs to ultimately eliminate damaged senescent, and damaged or dysfunctional mature erythrocytes from the circulation [204]

These differing observations are integrated within the DNA damage-cGAS-STING axis and collectively underscore the therapeutic complexity of targeting this pathway [76, 77]

10.1016/j.jbc.2023.105457 98 PrudovaA.BaumanZ.BraunA.VitvitskyV.LuS

As proof of principle, we have developed small molecules that target PTPs, termed redox-based probes (RBPs, Fig

4, reaction 3)

We help determine whether the project calls for a biologically relevant S-conjugate, a terminally derivatized GSH analogue, or a protected intermediate that preserves one functional group while another is modified

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