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Insomnia can arise as a result of depression, says Pigeon, but it is more common for insomnia to cause an episode of depression. And yet, for a condition this widespread and this consequential, the most common treatment is wildly off the mark

This discrepancy between mechanistic rationale and clinical outcomes represents a critical challenge in rheumatology, forcing a re-evaluation of how well our preclinical models truly capture the drivers of established axial disease

38 Mitochondrial disorders such as Leigh syndrome involve impaired energy production due to dysfunctional mitochondria, which disrupts the energy supply needed by neurons and results in neurodegeneration

doi: 10.1111/jcmm.14212 91 LeiSPengFLiMLDuanWBPengCQWuSJ

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Interferon (IFN) is a signal protein produced by infected or cancerous cells to bolster the immune response of neighboring cells (Marieb 2010)