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As a result, we encourage other nonprofit newsrooms, mission-aligned outlets, and advocacy organizations to republish our original content under the following conditions: 1

Add 1.0 mL bacteriostatic water to a 10 mg combo vial (5 mg + 5 mg) 10 mg/mL total (5 mg/mL of each component)

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10.20047/j.issn1673-7210.2021.19.004 158 WuC.PingcuiXu.WeixuanY.DanS.YanZ.WangN

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This review integrates mechanistic insights with translational advances, outlining how dysregulation of chaperones, autophagy-mitophagy, the ubiquitinproteasome system, and ER stress pathways drive human diseases, while highlighting emerging therapeutic platforms, from pharmacological chaperones and autophagy modulators to targeted protein degradation technologies, CRISPR screens, spatial biology, and AI-guided drug discovery