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PLoS Negl Trop Dis 6:e1916

Chaieb L, Krakau S, Reber TP, Fell J

Despite preliminary evidence pointing towards their significance (Dayon et al., 2017), other elements of the OCM pathway, namely those of the methionine cycle, have traditionally received relatively limited academic attention

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Histone-modifying enzymes (HATs/HDACs, demethylases) harbor catalytic cysteines and FeS or non-heme iron cofactors vulnerable to oxidation, transiently altering activity and locus accessibility

Interestingly, sex-specific differences emerged: females exhibited more pronounced downregulation of metabolic pathways, while males showed stronger immune activation