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A 2023 study focusing on ESCC patients in China also demonstrated that smokers had significantly worse overall survival and disease-free survival compared to non-smokers

Furthermore, we found that lower receptor availability of 2*-nAChRs in smokers with schizophrenia is associated with worse negative symptoms and worse performance on tests of executive function. The data seem to suggest that smoking might produce some clinical benefits for some patients by increasing the availability of receptor targets for nicotine in the brain

Whilst some people prefer tobacco-flavoured e-liquids to closely mimic their cigarette experience, others find that switching to menthol or fruit flavours helps break the psychological association with smoking

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