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Therefore, depletion of NADPH stores in G6PD-d has the potential to both limit the production of ROS by NOX family enzymes, while simultaneously expediting the accumulation of ROS from non-NADPH-dependent sources, such as the mitochondrial electron transport chain, peroxisomal -oxidation, oxidative protein folding, and other cytoplasmic enzymes (xanthine oxidase, cyclooxygenase, lipoxygenase) 95,96

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doi: 10.2147/JPR.S213912 8 AndreN.BraguerD.BrasseurG.GoncalvesA.Lemesle-MeunierD.GuiseS.et al

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