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A population-level study in India found curcumin intake up to 100 mg/day safe and associated with reduced cancer prevalence (Jutooru et al., 2010) FAO/WHO Joint Expert Committee on Food Additives (JECFA) considers 4 to 10 g of turmeric daily safe for healthy adults (Kocaadam and Sanlier, 2017)

Metformin, a drug used to treat type 2 diabetes, can also decrease absorption of B12 in the small intestine of 10 percent to 30 percent of patients

Vegetarians and Vegans : Since vitamin B12 is primarily found in animal products, those following plant-based diets are at increased risk of deficiency

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