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MahdavinezhadFGilaniMASGharaeiRAshrafnezhadZValipourJNashtaeiMSet al

As such, CRY1 emerges as a pro-tumorigenic factor that rhythmically controls DNA repair mechanisms and cell survival through temporal transcriptional regulation 27

the effect may be synergistically enhanced

For example, miR-139 increases the radiosensitivity of NSCLC by directly targeting cJUN and KPNA2, disrupting the NRF2 pathway and amplifying radiation-induced lipid peroxidation (122)

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Among HBV CA inhibitors, several drugs have entered phase II clinical trials, with GLS4 being the first nucleocapsid inhibitor to enter phase III clinical trials globally