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Selective deletion of RagA and RagB in FoxP3-expressing cells leads to spontaneous T cell activation, systemic inflammation, and early lethality

doi: 10.3389/fendo.2025.1627787 Received 13 May 2025 Accepted 27 June 2025 Published 18 July 2025 Volume 16 - 2025 Edited by Paolo Miccoli, Saint Camillus International University of Health and Medical Sciences, Italy Reviewed by Dmitry Aleksandrovich Zinovkin, Gomel State Medical University, Belarus Sijia Zhang, Heidelberg University, Germany Viktor Kravchenko, National Academy of Sciences of Ukraine, Ukraine Niladri Das, Nil Ratan Sircar Medical College and Hospital, India Updates Copyright 2025 Zhang, Tong, Zeng, Luo, Zhang, Feng, Xiao and Wang