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It is important to avoid characterizing reactive astrocytes solely as frenemies of neurons, as their transformation represents an adaptive mechanism aimed at enhancing survival

In several animal studies of tobacco/smoke exposure, local or systemic amino acid profiles, including certain BCAAs or their metabolites, have been reported to be upregulated

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The specific stereochemical features of the identified hit aligned with the previously published IDH1 R132H inhibitor BRD2879 57 , bearing different substituents installed through an alternate reaction scheme

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