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Significantly, the antimalarial potency of these compounds correlated well with their ability to disrupt erythrocyte redox balance in vitro (and slightly less strongly in vivo in mice), leading the authors to conclude that erythrocyte enolase is likely the common target that links these two characteristics

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The GH/IGF-1 axis is highly sensitive to small changes in GH or IGF-1 2 levels, which can trigger feedback suppression or amplify downstream effects

BSO decreases the glutathione content in liver and ileum mucosa BSO decreased hepatic glutathione by 48% in the infected animals in comparison with the control group (Figure 1A

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