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As the target can be located in intracellular compartment of the brain parenchyma, the main determinant of successful application of the approach for delivery of drugs with the brain parenchymal intracellular targets is an improvement of unbound steady-state concentrations of released parent drug in intracellular compartment in comparison to parent drug dosing

NayabDEFuDAliHKausarWAUroojSZafarMet alNano biomaterials based strategies for enhanced brain targeting in the treatment of neurodegenerative diseases: an up-to-date perspective

For example, untargeted LCMS has revealed that oxy-resveratrol protects SH-SY5Y cells against rotenone cytotoxicity mainly through modulating the dopamine biosynthesis pathway

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Views on glucocorticoid therapy in rheumatology: the age of convergence

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