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A study conducted in Nigeria revealed that approximately 216.8 million people reside in rural areas with limited access to healthcare facilities, including specialized care for chronic illnesses [55]

This intersection positions NETosis not merely as an antimicrobial strategy but as a cytotoxic effector mechanism driving sterile inflammation, endothelial dysfunction, and thrombo-inflammatory propagation in PCOS and related metabolic disorders

The Cys (or Hcy)-induced substitutionrearrangement cascade reaction and GSH-induced substitution reaction with the probe lead to the corresponding aminopyronin and thiopyronin dyes with distinct photophysical properties, enabling Cys/Hcy and GSH to be detected from visible and near-infrared (NIR) emission channels, respectively, in pure PB buffer with relatively fast kinetics and obvious fluorescence turn-on response

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During this washout period, the medication continues to exert diminishing effects