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Bariatric surgery is a collection of procedures that when effectively paired with healthy eating and regular exercise may help people who are obese lose weight

Eleftheriadis T, Pissas G, Sounidaki M, et al

High-dose supplementation appears most beneficial for those already experiencing deficiency or cognitive impairment, rather than the general population

Chem Rev 97:22432266 Illesinghe J, Guo CX, Garland R, Ahmed A, van Lierop BJ, Elaridi J, Jackson WR, Robinson AJ (2009) Metathesis assisted synthesis of cyclic peptides

The exact mechanism isnt known, but constipation and fatigue are two common symptoms of low B12

Rather than targeting fat cells directly, it intervenes in the brain's hunger-satiety circuitry, reducing the drive to eat