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Because standard capsules and powders must pass through the harsh environment of the stomach, high doses can irritate the gut lining

Cells 10:2663

Advances in clinical trial design for these patients fall under one of three categories: Combining the experimental drug with TMZ so as not to deprive patients of standard of care treatment

Mortensen R, Clemmensen HS, Woodworth JS, Therkelsen ML, Mustafa T, Tonby K, Jenum S, Agger EM, Dyrhol-Riise AM, Andersen P

In contrast, many antioxidants are exogenous and must be obtained from the diet, as their synthesis does not occur in eukaryotic cells (215)

Food Chem Toxicol 49:24222428