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A mutation in the gene leading to an impaired maturation of the protein with reduced membrane localization and abolished transport function has been described, 125 and a number of single-nucleotide polymorphisms have been identified, some of which are associated with an altered in vitro transport capability 180 Genetics of Diminished Bilirubin Conjugation Perhaps one of the most important advances in our understanding of the genomics of bilirubin metabolism is the elucidation of the UGT gene encoding the bilirubin-conjugating enzyme, UGT1A1

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