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Hereditary causes include genetic defects in the metabolism of amino acids, cholesterol, and fatty acids, such as propionyl-CoA carboxylase deficiency (aka propionic acidemia) and medium chain acyl-CoA dehydrogenase deficiency (36)

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Abbreviations PNIs: Peripheral nerve injuries MSCs: Mesenchymal stem cells GMSCs: Gingiva-derived mesenchymal stem cells GiSC: GMSC-derived Schwann-like cells -MEM: -Minimum essential medium FBS: Fetal bovine serum NEAA: Non-essential amino acid 2-ME: 2-Mercaptoethanol IL-10: Interleukin-10 TNF-: Tumor necrosis factor- IL-1: Interleukin-1 ELISA: Enzyme-linked immunoassay SIS-ECM: Small intestine submucosal extracellular matrix BDNF: Brain-derived neurotrophic factor GDNF: Glial cell-derived neurotrophic factor LPS: Lipopolysaccharide NC: Neural crest NCSC: Neural crest-derived stem cell TE/RM: Tissue engineering/regenerative medicine References Houschyar KS, Momeni A, Pyles MN, Cha JY, Maan ZN, Duscher D, et al

Knapp DW, Richardson RC, DeNicola DB, Long GG, Blevins WE