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Consistency over weeks and months is far more important than morning versus evening administration

Data availability The authors declare that all data supporting the findings of this study are provided in the Manuscript and its Supplementary Information/Source Data files

the evidence is mostly older and preclinical with limited independent replication

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Plasma PGA levels, reflecting glutathione (GSH) metabolic homeostasis, were analysed in three groups represented by: healthy controls with the wild-type TTR genotype, asymptomatic carriers of the TTR-V30M mutation, and symptomatic patients with TTR-V30M amyloidosis

whether supplementation earlier than this is beneficial is unknown