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While the ceiling culture technique was developed to circumvent this, it often induces a morphological shift from unilocular to multilocular phenotypes and presents a risk of dedifferentiation of the mature adipocytes as well ( 3.2 2D models of lipedema Many 2D in vitro models of lipedema have utilized adipose-derived stem cells (ASCs) isolated from patient samples ( expression in lipedema-differentiated adipocytes compared to healthy-differentiated adipocytes ( Since lipedema involves significant vascular changes, researchers have increasingly incorporated endothelial cells into their disease models

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10.1038/s41572-021-00280-3 Nat

Methylation ProfileThe Methylation Profile analyzes various amino acids in plasma to evaluate the cellular methylation of DNA, proteins, and neurotransmitters