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Description

Mutations in the Ta pHAT were introduced into the construct expressing GST-tagged Ta pHAT domain using site-directed mutagenesis based on the QuikChange site-directed mutagenesis kit from Stratagene

Matrix metalloproteinase interactions with collagen and elastin[J]

In particular, considering that both of these transcription factors also play critical roles in normal cell physiology, elucidating the common signaling pathways associated with their increase in tumors and revealing the molecular mechanisms underlying the correlation between these factors are expected to enable the development of the selective regulation of HIFs and NRF2 in cancers