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The copolymer (A) in the first coating preferably comprises 50 to 80 mol-% ethyl acrylate repeating units and 20 to 50 mol-% methyl methacrylate repeating units, more preferably 60 to 75 mol-% ethyl acrylate repeating units and 25 to 40 mol-% methyl methacrylate repeating units, even more preferably 64 to 68 mol-% ethyl acrylate repeating units and 32 to 36 mol-% methyl methacrylate repeating units

The synthesis and remodeling of Acan occurs at early stages of cartilage formation and remains low during the middle and late stages [59,60,61], while Col-2 expression is consistently high throughout the early and late stages of cartilage formation [62]

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These areas (upper arms, outer-upper thighs, and belly area) have fewer blood vessels than muscle, which allows nutrients to absorb more slowly and consistently over time

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