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Something seems to be going on at cell level

Neurosteroids: deficient cognitive performance in aged rats depends on low pregnenolone sulfate levels in the hippocampus

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These hormones play important roles in various bodily functions, including muscle growth, bone density, and cell repair

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The soluble factors are important in engaging monocytes, macrophages, and neutrophils in the phagocytosis [34], during which the foreign agents are destroyed by lysosomal enzymes, acidic pH, and radical attacks