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Elimination occurs primarily through renal clearance, with a plasma half-life of approximately 2-4 hours in rodent models

Mechanistically, ROS can activate numerous signaling pathways that contribute to cancer initiation and progression such as, but not limited to, the mitogen-activated protein (MAP) kinases (MAPKs), the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT), and the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathways [43]

Autophagy 2023;19:2175-95

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Underlying Health Conditions : Comorbidities such as autoimmune disorders, liver or kidney issues, or gastrointestinal diseases may slow recovery and affect how BPC-157 works