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Direct targeting of SLC7A11 includes the use of inhibitors: sulfasalazine (128, 129), erastin (130, 131), imidazole ketone erastin (IKE) (132), sorafenib (133, 134), and HG106 (78)

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In contrast, [email protected] demonstrated delayed-onset penetration kinetics, achieving maximal epidermal accumulation at 6 h post-administration with limited dermal distribution and negligible subcutaneous deposition

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This deficiency can cause health issues such as anemia, fatigue, and a lack of focus

Naji L, Dennis B, Rosic T, Wiercioch W, Paul J, Worster A, et al