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Unlike peptides that work on growth factors or metabolic pathways, Epithalon directly influences telomere length and cellular aging at the chromosomal level

Funding The National Key Research and Development Program of China (2016YFD0101900) supported this work

In cancer, the same H 2 O 2 signals that sustain growth and EMT coexist with antioxidant rewiring, creating a therapeutic window where node- and compartment-specific interventions (NOX/NOS modulation, mitochondrial quality control, iron/ferroptosis management, calibrated RSS support) outperform blanket scavenging (Lankheet et al

Hormonal changes accelerate oxidative stress, often bringing fatigue, hot flashes, and skin shifts

This effect is dose-dependent, requiring higher doses for mucociliary stimulation than for bronchodilation [76]

doi: 10.3390/ijms20133292 146 RysJPMonteiroDAAllistonT