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This provides insight into the mechanism of taurine benefit through global RAAS suppression and similar to studies in hypertensive rats, suggests that benefit might be best realized in patients with the most baseline RAAS activation 27

The use of GPX4 inhibitors in vivo (in living organisms) presents several challenges, particularly due to the risk of excessive systemic toxicity caused by nonselective inhibition of GPX4

Plasma concentrations decline significantly with age, from approximately 200 ng/mL in young adults to below 80 ng/mL in older individuals

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