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Lead interferes with calcium signaling and hormone regulation [211], while chromium (VI) undergoes intracellular reduction to reactive intermediates that form DNA crosslinks and strand breaks, initiating mutagenesis [212]

Data analysis Pre-processing, normalisation and false discovery rate calculations Peptide-wise linear mixed effects models (LMMs) were used to normalise the log 2 -transformed data and adjust for batch effects, with consideration of sample analysis order while allowing an individual baseline for each experimental batch

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