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Since the sequences in the cluster did not provide enough evolutionary information, we extended our analysis using a Blast search (Altschul et al., 1990) in Uniprot using P01730 as a template

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However, since apoE isoforms also affect A and tau aggregation, which are known to promote microglial activation, a direct effect of apoE isoforms on microglial activation in AD is complex to conclude [146148]

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