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This termination underscores the ongoing challenges in recruitment and the potential lack of clinical benefit for unselected patients, reinforcing the necessity for precision medicine to identify specific phenotypes that may respond to bronchodilator therapy

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In various studies, increased expression of the pro-apoptotic molecules Bak, Bim, and Bax, decreased expression of apoptosis inhibitor molecules such as Bcl-2 and activation of caspases have been observed after statin therapy