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In the case of histone H3, the peptide targeted the exposed N-terminal domain, known as a tail, which is known for undergoing post-translational modifications

The latter acts as a chaperone for monocarboxylate transporter 1 (MCT1) and MCT4, facilitates their proper expression at the cell surface, and prevents their degradation

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In low-glucose treated bronchial epithelial cells, the conversion of serine to glycine is consistently increased, along with the upregulation of the mitochondrial one-carbon metabolism enzymes, serine hydroxymethyltransferase (SHMT2) and methylenetetrahydrofolate dehydrogenase (MTHFD2) (Haitzmann et al., 2024)

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